CRISPR Uncovered: The Future of Gene Editing and Human Health
Introduction In 2012, two scientists—Jennifer Doudna and Emmanuelle Charpentier—made a discovery that would change biology forever. They unveiled a gene-editing tool called CRISPR-Cas9, inspired by a bacterial immune system, that allowed scientists to cut and modify DNA with unmatched precision. This breakthrough won them the 2020 Nobel Prize in Chemistry and launched a revolution in genetic medicine, biotechnology, and agriculture. What is CRISPR and How Does It Work? CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a molecular tool that works like GPS-guided scissors. It uses a guide RNA (gRNA) to find a specific DNA sequence and a Cas9 enzyme to cut the DNA at that precise location. Once the DNA is cut, the cell naturally attempts to repair it. Scientists can manipulate this repair process to delete, insert, or change genetic material. What Can CRISPR Do Today? CRISPR is already being used in laboratories and clinics around the world. Recent milestones incl...